Some Basic Aspects of HLA-G Biology

نویسندگان

  • Estibaliz Alegre
  • Roberta Rizzo
  • Daria Bortolotti
  • Sara Fernandez-Landázuri
  • Enrico Fainardi
  • Alvaro González
چکیده

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.

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عنوان ژورنال:

دوره 2014  شماره 

صفحات  -

تاریخ انتشار 2014